Institute of Organic Chemistry

Molecular Dynamics in NMR
&
Molecular Interactions

Polish Academy of Sciences

DNA analogues

DNA analoguesThe main aim of the project is to investigate how the versatile properties of cyclidene complexes can be exploited in much larger DNA-based systems. In particular, the project is concerned with:

  1. The synthesis and verifying the effectiveness of novel DNA sensors, that are structurally enriched with transition metal complexes (structure 1).
  2. Obtaining and studying the self-assembly process and investigating the properties of advanced metal-containing assemblies that utilise π-π interactions. It is assumed that two versions of such systems will be synthesised:
    1. oligonucleotide derivatives containing cyclidene complexes used as bridges between the two strands of a DNA duplex, to form a linear stack of macrocycles within a double helix (structure 2a),
    2. DNA analogues composed of two strands joined together by π-π interactions between cyclidene units (structure 2b).

The research is financially supported by the Foundation for Polish Science