The aim of this project is to develop a new method for the synthesis of carbonyl compounds bearing substituents at both α and β positions. The transformation will comprise of two photochemical processes: photoinduced electron-transfer and photochemical singlet oxygen generation, both accompanied by enamine catalysis.

Tasks of the project include: studies on scope and limitation of photochemical β-functionalisation of aldehydes and photochemical α-hydroxylation of β-substituted aldehydes, determination of common conditions that allow to perform β-functionalisation and α-hydroxylation as a ‘one-pot’ procedure. All work involving synthesis will be performed according to the highest standards in organic synthesis. Reactions under visible light irradiation will be perform in a professional photoreactor, under LED lighting bulb or simple household compact fluorescent light bulb.

Photochemical processes, due to a unique reactivity of molecules in their excited state offer a simple way to perform difficult chemical transformations i.e C-C bond formation or oxidation without toxic oxidants. Combining in a ‘one-pot’ procedure two unique photochemical processes: β-arylation/alkylation of aldehydes and α-hydroxylation of aldehydes substituted at β position allow to create new methods for the synthesis of α,β-disubstituted aldehydes and their derivatives such as diols and lactones. These multisubstituted molecules are valuable starting materials in organic synthesis.