Sustainable photochemical transformations of diazo reagents as a source of reactive intermediates

Objective:

Are you interested to tackle the challenges associated with photocatalysis in a coherent and comprehensive fashion? To unveil general reactivity modes of diazo compounds under visible light-irradiation, we will develop their solar-driven reactions and determine reactive intermediates (singlet or triplet carbenes, radicals, others) generated during these processes. Applications are invited for a post-doc position in a research grant "Sustainable photochemical transformations of diazo reagents as a source of reactive intermediates" funded by the National Science Centre, Poland.

Short description of the project:

Drawing inspiration from photosynthesis, scientists challenged the use of visible light for the activation of organic molecules and the discovery unknown solar-driven transformations. Plethora of organic compounds have been investigated in terms of their photochemical activity. However, the fact that diazo compounds possess their intrinsic chromophore (-C=N⁺=N^-) puts them in a unique position among many reagents that can absorb visible light and hence are suitable for solar-driven transformations. To date, they are extensively studied in metal catalyzed reactions and proved to undergo a range of unusual transformations, furnishing even complex molecules with impressive stereoselectivities. As traces of toxic metals are unacceptable by pharmaceutical industry, greener methodologies are in high demand.

The main objective of this proposal is to unveil general reactivity modes of diazo compounds under visible light-irradiation. We will develop their solar-driven reactions and determine reactive intermediates (singlet or triplet carbenes, radicals, others) generated during these processes. To this end, we will elaborate direct photolysis of diazo compounds which absorb in the blue region in C-H insertions. For compounds unreactive under visible light-irradiation, photocatalyzed transformations in the presence of a photosensitizer or a photoredox catalyst represent an alternative.

Scope of work:

• design, preparation of diazo compounds absorbing visible light and determination of their optical properties;
• studying reactions of diazo compounds in the presence of photoredox catalysts;
• scope and limitation studies;
• analytical characterization of synthesized;
• preparation of manuscripts.

Requirements:

• master degree in chemistry;
• other skills include analysis and interpretation of experimental data (NMR, MS, UV/Vis);
• demonstrated experience in research work will be an asset;
• effective written and oral communication skills in English.
• be a highly motivated university graduate, within 4 years after receiving a relevant MSc degree;
• effective written and oral communication skills in English.
• be excellent in oral and written English with good presentation skills.;

Other required skills include:

• strong motivation for scientific work, ambition, creativity, goal-orientation, responsibility, ability to work independently as well as in a group; excellent communications, organization and time management skills, willingness to learn, analytical thinking and critical problem solving skills;

Our offer:

• We offer a post-doctoral position (full-time employment) in the Institute of Organic Chemistry PAS with brutto brutto salary in the amount of 10 000 PLN per month financed from the NSC MAESTRO 12 project.

Questions?

Do you have questions about this vacancy? Or do you want to know more about our organization? Please contact: Prof. Dorota Gryko, dorota.gryko@icho.edu.pl

Job application

The ICHO PAN is an equal-opportunity employer. We prioritize diversity and are committed to creating an inclusive environment for everyone. We value a spirit of enquiry and perseverance, provide the space to keep asking questions, and promote a culture of curiosity and creativity.

Do you recognize yourself in the job profile? Then we look forward to receiving your application by 10 July 2021.

Applications should be sent to: rekrutacja@icho.edu.pl (please input email subject as ‘Dorota Gryko’)

Applications in only one .pdf should include:

• scientific curriculum vitae, including a list of scientific achievements (scholarships, publications, conference presentations, etc.);
• motivation letter;
• one recommendation letter;
• a transcript of the grades/credits received; during the last stage of studies and grade point average.

The IChO PAN is the party responsible for processing your personal data (the 'controller') within the meaning of the General Data Protection Regulation (‘GDPR’).

The selection procedure includes interview and a reference check. The interview will be done by video calls and include a presentation of your master thesis, and questions from organic chemistry at the master level. Please read the Charter and Code for recruitment