Vitamin B12 (cobalamin) is an essential nutrient for mammals and certain bacteria. As an exogenous compound, cobalamin reaches mammalian cells via a system of transport proteins and this fact makes it an attractive candidate for the delivery of cargoes into cells. Development of conjugates requires suitably designed building blocks and vitamin B12 possesses a number functional groups susceptible to chemical modifications, however complex nature of cobalamin makes them extremely challenging.
Our lab develops new methodologies allowing for the preparation of cobalamin derivatives which can be used for the synthesis of vitamin B12 conjugates with biologically relevant molecules.
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